منابع مشابه
EFTUD2 on innate immunity.
Host innate immunity is the first line of defense against invasion of pathogens and determines the outcome of the infection. The host cells recognize pathogens as nonself via pattern-recognition receptors including Tolllike receptors (TLRs) and the RIG-I like receptors (RLRs), follow to induce local antiviral defense by producing interferon and proinflammatory cytokines to combat viral infectio...
متن کاملComparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity.
The extent of the innate immune response is regulated by many positively and negatively acting signaling proteins. This allows for proper activation of innate immunity to fight infection while ensuring that the response is limited to prevent unwanted complications. Thus mutations in innate immune regulators can lead to immune dysfunction or to inflammatory diseases such as arthritis or atherosc...
متن کاملSeminar on Innate Immunity
Viral components induce strong type I IFN responses through the activation of toll-like receptors (TLRs) and intracellular cytoplasmic receptors such as an RNA helicase RIG-I and/or MDA5. According to recent studies, the NF-κB essential modulator NEMO (also called IKKγ) is crucial for this virus-induced antiviral response. However, the precise roles of signal activation by NEMO adaptor have not...
متن کاملInnate immunity
From the discovery of antibodies in the late nineteenth century until very recently, the focus of most research in immunology has been the so-called adaptive immune response. Adaptive immune responses are highly specific for a given microorganism and it is the T and B lymphocytes of the adaptive immune response, and the antibodies produced by the B lymphocytes, that are responsible for lasting ...
متن کاملInnate immunity.
Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity plays in the pathogenesis of many human infe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.5863